Today’s episode is brought to you by Strata. Modernize your IAM with Identity Orchestration. Visit https://strata.io/firstprinciples to learn more!

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Episode 15: Bryan Johnson spends $2m/year to not die. But this is more than just a health craze — it’s the birth of a new, secular religious movement. Here’s what Bryan believes.

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(00:00 ) - Introduction
(01:13 ) - Zeroth Principles Thinking: Going Beyond First Principles
(04:05 ) - The Journey to "Don't Die": Bryan's Thought Experiments and Realizations
(07:28 ) - Is "Don't Die" a Religion? Examining the Parallels
(10:40 ) - Bryan's Roles in "Don't Die": Philosopher, Embodiment, Message Bearer
(13:05 ) - Sponsor Break
(14:08 ) - Quantifying Death: Introducing "Die Scores" for Behaviors and Choices
(17:03 ) - What is Death and What is Aging? A First Principles Perspective
(19:40 ) - Measuring Biological Age: Organ by Organ Analysis of Bryan's Body
(23:48 ) - The Penis as a Marker of Overall Health and Vitality
(26:33 ) - Epigenetic Clocks and the Pace of Aging Calculated Tests
(30:18 ) - Bryan's Experience with Follistatin Gene Therapy
(32:25 ) - Kernel: Building a Mass Market Brain Interface with Time-Domain FNIRS
(36:48 ) - The Power Law Interventions: Identifying the Most Effective Longevity Levers
(39:22 ) - Assembling a Team of Scientific Misfits to Tackle Aging
(41:05 ) - Dreaming Up Ideas: Bryan's Nocturnal Creativity
(42:15 ) - Telomeres and the Risks of Telomerase Gene Therapy
(44:38 ) - Reflections on the Challenges of Commercializing Deep Tech
(46:29 ) - Conclusion: Banding Together to Build an Amazing Future

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Links:

• Christian Keil – https://twitter.com/pronounced_kyle
• Bryan Johnson - https://x.com/bryan_johnson
• Bryan Johnson Personal Website - https://www.bryanjohnson.com/
• Blueprint - https://blueprint.bryanjohnson.com/

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Production and marketing by The Deep View (https://thedeepview.co). For inquiries about sponsoring the podcast, email team@firstprinciples.fm

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Checkout the video version here → http://tinyurl.com/4fh497n9

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